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ALX 5407 hydrochloride

SIGMA/SML0897 - ≥98% (HPLC)

Synonym: ALX-5407 hydrochloride; N-[3-(4′-Fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine hydrochloride; NFPS hydrochloride

CAS Number: 200006-08-2
Empirical Formula (Hill Notation): C24H24NO3F·HCl
Molecular Weight: 429.91
MDL Number: MFCD09971056
Linear Formula: C24H24NO3F·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0897-5MG 5 mg
 $132.00
1/EA		 Add To Favorites
45-SML0897-25MG 25 mg
 $417.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
InChI key RPDGSZCYSJWQEE-GNAFDRTKSA-N
Quality Level 100 
SMILES string Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O
solubility DMSO: 5 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Application: ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.
Biochem/physiol Actions: ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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