Mps1-IN-3

SIGMA/SML0898 - ≥98% (HPLC)

Synonym: 1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol

Empirical Formula (Hill Notation): C₂₆H₃₁N₇O₄S
Molecular Weight: 537.63
Linear Formula: C₂₆H₃₁N₇O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0898-5MG	5 mg	$150.00 1/EA		Add To Favorites
45-SML0898-25MG	25 mg	$598.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow to dark yellow
form	powder
InChI	1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32)
InChI key	OFRMASLPWOMYHN-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.
Biochem/physiol Actions:	Mps1 mediates phosphorylation of kinetochore scaffold 1.
Biochem/physiol Actions:	Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC₅₀ value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC₅₀ value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.
General description:	Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
Safety Statements	46
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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