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Mps1-IN-3

SIGMA/SML0898 - ≥98% (HPLC)

Synonym: 1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol

CAS Number: 1609584-72-6
Empirical Formula (Hill Notation): C26H31N7O4S
Molecular Weight: 537.63
Linear Formula: C26H31N7O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0898-5MG 5 mg
 $131.00
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assay ≥98% (HPLC)
color light yellow to dark yellow
form powder
InChI 1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32)
InChI key OFRMASLPWOMYHN-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.
Biochem/physiol Actions: Mps1 mediates phosphorylation of kinetochore scaffold 1.
Biochem/physiol Actions: Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.
Biochem/physiol Actions: Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1.
General description: Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
Safety Statements 46
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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