Windorphen
SIGMA/SML0899 - ≥98% (HPLC)
Synonym: (Z)
CAS Number: 19881-70-0
Empirical Formula (Hill Notation): C17H15ClO3
Molecular Weight: 302.75
Linear Formula: C17H15ClO3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H15ClO3/c1-20-14-7- |
| InChI key | VNRALGZMXHFBPG-MSUUIHNZSA |
| Quality Level | 100  |
| shipped in | wet ice |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage condition | protect from light |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Windorphen is a selective Wnt/β-catenin signaling inhibitor acting through selective inhibition of p300, a histone acetyltransferase (HAT) that also acts as a critical coactivator of β-catenin, a transcription factor that mediates the Wnt signaling pathway involved in embryogenesis and cancer cell survival. Windorphen blocks Wnt signaling by selectively disrupting the association of p300 with the C-terminal transactivation domain of β-catenin-1. Windorphen does not inhibit the closely related CREB-binding protein (CBP). Windorphen induced apoptosis in several Wnt-dependent tumor cell lines including colon adenocarcinoma SW480and RKO and prostate cancer cell lines DU145 and PC3. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Other Notes: | Light sensitive |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |