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ABO dihydrochloride

SIGMA/SML0904 - ≥98% (HPLC)

Synonym: 6-Amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine

CAS Number: 896126-03-7 (free base)
Empirical Formula (Hill Notation): C9H12N2O2 · 2HCl
Molecular Weight: 253.13
Linear Formula: C9H12N2O2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0904-5MG 5 mg
 $120.00
1/EA		 Add To Favorites
45-SML0904-25MG 25 mg
 $476.00
1/EA		 Add To Favorites
assay ≥98% (HPLC)
color , light yellow to grey to brown
form powder
Quality Level 100 
solubility H2O: 25 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: ABO is a modulator of Annexin A7 (ANXA7) GTPase, a member of the annexin family of calcium/phospholipid-binding proteins. ABO can directly bind to Annexin A7 and inhibit its phosphorylation. Annexin A7 is involved in several processes especially in the process of membrane fusion and exocytosis. ABO is a GTPase, and both GTP-binding and Protein kinase C (PKC) activity are important in regulating its function to potentiate calcium-dependent membrane fusion. Annexin A7 has several other activities, not fully understood. ABO suppressed oxidized low-density lipoprotein (oxLDL)-induced phosphatidylcholine-specific phospholipase C (PC-PLC) activity, inhibiting apoptosis and promoting autophagy in vascular endothelial cells, indicating that ANXA7 is an endogenous regulator of phosphatidylcholine-specific phospholipase C (PC-PLC). ABO significantly reduced atherosclerotic plaque area and reduced lipid deposition and pro-inflammatory macrophages in apolipoprotein E-/- mice. ABO should be a valuable tool to study the complex functions of Annexin 7.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41106300

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