Apoptolidin A Ready Made Solution
SIGMA/SML0907 - 1 mg/mL in DMSO
Synonym: Apoptolidin; FU 40A
CAS Number: 194874-06-1
Empirical Formula (Hill Notation): C58H96O21
Molecular Weight: 1129.37
EC Number: 200-664-3
Linear Formula: C58H96O21
Product Type: Chemical
antibiotic activity spectrum | fungi |
biological source | Amycolatopsis sp. |
concentration | 1 mg/mL in DMSO |
form | DMSO solution |
InChI | 1S/C58H96O21/c1-29-17-16- |
InChI key | WILMROCKORZEMQ-XIQAQMKHSA |
mode of action | enzyme | inhibits |
Quality Level | 200 |
shipped in | dry ice |
SMILES string | CC(/C=C1C)=CC(C)=C[C@@ |
storage temp. | −20°C |
Biochem/physiol Actions: | Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F0F1-ATPase. Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E1A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported. |
General description: | Chemical structure: macrolide |
RIDADR | NA 1993 / PGIII |
WGK Germany | WGK 2 |
Flash Point(F) | 188.6 °F |
Flash Point(C) | 87 °C |
Storage Temp. | −20°C |
UNSPSC | 12352200 |