ML221
SIGMA/SML0919 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 877636-42-5
Empirical Formula (Hill Notation): C17H11N3O6S
Molecular Weight: 385.35
Linear Formula: C17H11N3O6S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C17H11N3O6S/c21-14-8-1 |
InChI key | UASIRTUMPRQVFY-UHFFFAOYSA |
Quality Level | 100 |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC50 of 1.75 μM. |
Biochem/physiol Actions: | ML221 is capable of suppressing the cultured-endothelial cell proliferation. In oxygen-induced retinopathy (OIR) mice model, ML221 can block the pathological angiogenesis and increase the recovery of normal vessels into the ischemic regions in the retina. It can also inhibit the formation of neovascular tufts. |
Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |