NSC130813
SIGMA/SML0922 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 1082532-95-3
Empirical Formula (Hill Notation): C26H27ClN4O2 · 3HCl
Molecular Weight: 572.35
Linear Formula: C26H27ClN4O2 · 3HCl
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥98% (HPLC) |
| color | yellow to orange |
| form | powder |
| Quality Level | 100  |
| solubility | H2O: 10 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C. |
| Biochem/physiol Actions: | NSC130813 is a Xeroderma Pigmentosa Group F (XPF) antagonist, inhibitor of nucleotide excision repair (NER) mechanism. |
| Other Notes: | air sensitive |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |