ML167
SIGMA/SML0924 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 1285702-20-6
Empirical Formula (Hill Notation): C19H17N3O3
Molecular Weight: 335.36
Linear Formula: C19H17N3O3
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | off-white to gray-brown |
| form | powder |
| InChI | 1S/C19H17N3O3/c1-12-2-4-1 |
| InChI key | ROCFOIBAEVAOLQ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | N(Cc4[o]c(cc4)C)c1ncnc2c1 |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | ML167 is a selective inhibitor of of Cdc2-like kinase 4 (Clk4). |
| Biochem/physiol Actions: | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk’s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 46 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |