ML167
SIGMA/SML0924 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 1285702-20-6
Empirical Formula (Hill Notation): C19H17N3O3
Molecular Weight: 335.36
Linear Formula: C19H17N3O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | off-white to gray-brown |
form | powder |
InChI | 1S/C19H17N3O3/c1-12-2-4-1 |
InChI key | ROCFOIBAEVAOLQ-UHFFFAOYSA |
Quality Level | 100 |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk’s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 46 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |