Diapocynin
SIGMA/SML0927 - ≥98% (HPLC)
Synonym: 1,1′-(6,6′-Dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone; 4′,4′′′-Dihydroxy-5′,5′′′-dimethoxy-3′,3′′′-biacetophenone (8CI); Dehydrodiacetovanillone
CAS Number: 29799-22-2
Empirical Formula (Hill Notation): C18H18O6
Molecular Weight: 330.33
Linear Formula: C18H18O6
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | room temp |
| Biochem/physiol Actions: | Diapocynin is a covalent dimer of apocynin, and a functional metabolite of the same. It is generated by neutrophil activation via myeloperoxidase-mediated oxidation. Studies show that diapocynin has greater neuroprotection compared to apocynin. |
| Biochem/physiol Actions: | Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. |
| Biochem/physiol Actions: | Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. Diapocynin attenuates oxidative damage and neuroinflammatory responses in animal model of Parkinson’s disease. Diapocynin reverses deficient motor coordination in LRRK2R1441Gtg mice of PD. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H410 |
| Precautionary statements | P273 - P501 |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |