Synonym: 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide; 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
CAS Number: 1030203-81-6
Empirical Formula (Hill Notation): C14H12ClN5O2S
Molecular Weight: 349.80
Linear Formula: C14H12ClN5O2S
Product Type: Chemical
assay |
≥95% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 |
solubility |
DMSO: 5 mg/mL, clear (warmed) |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
HS38 is a potent and selective ATP-competitive inhibitor of Death-associated protein kinases DAPK1 (IC50 = 200 nM, 89% inhibition at 10 RM) and ZIPK (Zipper-interacting protein kinase, also called DAPK3) that regulate programmed cell death, and also inhibits the closely related PIM3 kinase (IC50 = 200 nM, 76% inhibition at 10 RM). In addition to mediating apoptosis, DAPK1 and ZIPK regulate both non-muscle and smooth muscle myosin phosphorylation. HS38 specifically targeted ZIPK in smooth muscle, and decreased contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle. |
Packaging: |
10, 50 mg in glass bottle |
Purity |
≥95% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |