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Psoralidin

SIGMA/SML0932 - ≥98% (HPLC)

Synonym: 3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one; 3,9-Dihydroxy-2-prenylcoumestan

CAS Number: 18642-23-4
Empirical Formula (Hill Notation): C20H16O5
Molecular Weight: 336.34
MDL Number: MFCD10566617
Linear Formula: C20H16O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0932-5MG 5 mg
 $64.80
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45-SML0932-25MG 25 mg
 $213.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3
InChI key YABIJLLNNFURIJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC(C)=CCC1=C(C=C(OC2=O)C(C(OC3=C4)=C2C3=CC=C4O)=C1)O
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: Psoralidin is a coumestan derivative extracted from Psoralea corylifolia seeds. It exhibits anti-inflammatory property by inhibiting both cyclooxygenases-2 (COX-2) and 5-lipoxygenase (5-LOX) expression. In addition to its anti-cancer and anti-inflammatory activities, psoralidin also exhibits anti-oxidant, anti-bacterial, and anti-depressant activities. Psoralidin is implicated in the regulation of insulin signaling. It is used as a key ingredient in traditional medicines for bleeding, enuresis, pollakiuria, vitiligo, and psoriasis.
Biochem/physiol Actions: Psoralidin is a furanocoumarin natural product used in Chinese medicine. Psoralidin, a PTP1B inhibitor, has been shown to have anticancer activity with a variety of mechanisms proposed. Psoralidin induces ROS generation in androgen-independent prostate cancer cells, leading to inhibition of cell proliferation. Psoralidin has been found to downregulate NOTCH1 signaling, causing growth arrest in both breast cancer stem cells and breast cancer cells.
Biochem/physiol Actions: Psoralidin is a furanocoumarin natural product with anticancer activity; PTP1B inhibitor.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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