Teriflunomide
SIGMA/SML0936 - ≥98% (HPLC)
Synonym: (Z)
CAS Number: 163451-81-8
Empirical Formula (Hill Notation): C12H9F3N2O2
Molecular Weight: 270.21
Linear Formula: C12H9F3N2O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C12H9F3N2O2/c1-7(18)10 |
InChI key | UTNUDOFZCWSZMS-YFHOEESVSA |
Quality Level | 100 |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | −20°C |
Application: | Teriflunomide has been used as a dihydroorotate dehydrogenase (DHODH) inhibitor. |
Biochem/physiol Actions: | Teriflunomide is an orally available anti-inflammatory immunomodulator. It blocks the activity of dihydroorotate dehydrogenase, preventing pyrimidine synthesis and T and B cell proliferation and function. Teriflunomide has been used to treat rheumatoid arthritis and was recently approved for multiple sclerosis. |
Packaging: | 10, 50 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |