Teriflunomide

SIGMA/SML0936 - ≥98% (HPLC)

Synonym: (Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; A 1726; A77-1726; A771726; Flucyamide; HMR 1726; N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide; SU 20

CAS Number: 163451-81-8
Empirical Formula (Hill Notation): C₁₂H₉F₃N₂O₂
Molecular Weight: 270.21
Linear Formula: C₁₂H₉F₃N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0936-10MG	10 mg	$81.10 1/EA	Add To Favorites
45-SML0936-50MG	50 mg	$345.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
InChI key	UTNUDOFZCWSZMS-YFHOEESVSA-N
Quality Level	100
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C

Application:	Teriflunomide has been used as a dihydroorotate dehydrogenase (DHODH) inhibitor.
Biochem/physiol Actions:	Teriflunomide is an orally available anti-inflammatory immunomodulator.
Biochem/physiol Actions:	Teriflunomide is an orally available anti-inflammatory immunomodulator. It blocks the activity of dihydroorotate dehydrogenase, preventing pyrimidine synthesis and T and B cell proliferation and function. Teriflunomide has been used to treat rheumatoid arthritis and was recently approved for multiple sclerosis.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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