PFI-3
SIGMA/SML0939 - ≥98% (HPLC)
Synonym: (E)
Empirical Formula (Hill Notation): C19H19N3O2
Molecular Weight: 321.37
Linear Formula: C19H19N3O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | yellow to orange |
form | powder |
InChI | 1S/C19H19N3O2/c23-17-6-2- |
InChI key | INAICWLVUAKEPB-QSTFCLMHSA |
Quality Level | 100 |
SMILES string | OC1=C(C(/C=C/N2[C@H](C3)C |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) is a transcriptional activator and is a component of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. SMARC4 (also known as BRG1) and the related protein SMARCA2 (also known as BRM) contain a bromodomain that is structurally similar to the PolyBromo1 (PB1) 5 bromodomain. PFI-3 is a selective chemical probe for SMARCA bromodomains that inhibits SMARCA2, SMARCA4 and PB1(5) bromodomains. For full characterization details, please visit the PFI-3 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
Features and Benefits: | PFI-3 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC . |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |