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Nepicastat hydrochloride

SIGMA/SML0940 - ≥95% (HPLC)

Synonym: 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride; SYN-117

CAS Number: 170151-24-3
Empirical Formula (Hill Notation): C14H15F2N3S · HCl
Molecular Weight: 331.81
MDL Number: MFCD00954638
Linear Formula: C14H15F2N3S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0940-5MG 5 mg
 $118.00
1/EA		 Add To Favorites
45-SML0940-25MG 25 mg
 $475.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C14H15F2N3S.ClH/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20;/h3,5,7,10H,1-2,4,6,17H2,(H,18,20);1H/t10-;/m0./s1
InChI key DIPDUAJWNBEVOY-PPHPATTJSA-N
Quality Level 100 
SMILES string FC1=CC2=C(CC[C@H](N3C(CN)=CNC3=S)C2)C(F)=C1.Cl
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Application: Nepicastat hydrochloride has been used as an inhibitor of dopamine β-hydroxylase (DBH) in zinc finger protein 521 (ZFP521) deficient mice.
Biochem/physiol Actions: By inhibiting dopamine β-hydroxylase (DβH), nepicastat enhances dopamine levels and norepinephrine levels in brain.
Biochem/physiol Actions: Nepicastat is a potent and selective dopamine β-hydroxylase inhibitor
Biochem/physiol Actions: Nepicastat is a potent and selective dopamine β-hydroxylase inhibitor with an IC50 of 9 nM and negligible affinity (>10 μM) for twelve other enzymes and thirteen neurotransmitter receptors tested. Nepicastat has been shown to attenuate multiple aspects of cocaine-seeking behavior and suppress cocaine-primed reinstatement of cocaine seeking in rats, and has been in clinical trials for cocaine dependence. Nepicastat also suppressed chocolate self-administration and reinstatement of chocolate seeking in rats.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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