YM-1
SIGMA/SML0943
Synonym: 2-
CAS Number: 409086-68-6
Empirical Formula (Hill Notation): C20H20ClN3OS2
Molecular Weight: 417.98
Linear Formula: C20H20ClN3OS2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | orange to dark red |
| form | powder |
| Quality Level | 100  |
| solubility | H2O: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Application: | YM-1 has been used as a Hsp70 (heat shock protein) inhibitor in cell viability assay. |
| Biochem/physiol Actions: | YM-1 is a Hsp70 modulator; anticancer agent. |
| Biochem/physiol Actions: | YM-1 modulates Hsp70 activity by binding to the nucleotide-binding domain of ADP- but not ATP-bound Hsp70, stabilizing Hsp70 in its ADP-bound conformation. The ADP-bound state has tight affinity for its substrates, promoting their ubiquitination and degradation, and a greatly reduced off rate compared to the ATP-bound state. YM-1 appears to behave in a similar manner to Hip, a Hsp70 co-chaperone that stabilizes Hsp70 in its ADP-bound conformation which favors degradation of misfolded substrates such as those involved in various neurodegenerative diseases. YM-1 also has anticancer activity, which could be due to enhanced ubiquitination and clearance of Akt, a major survival kinase. In studies with multiple cancer lines, YM-1 was found to selectively target cancer cells over normal cells and to overcome tamoxifen resistance in a tamoxifen-resistant MCF7 cell model. YM-1 had greater efficacy and cytosolic localization than the closely related MKT-077 (M5449). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |