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Nilvadipine

SIGMA/SML0945 - ≥98% (HPLC)

Synonym: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester; 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; FK-235; FR-34235; Isopropyl 6-cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; Nivadipine; Nivaldipine; SKF-102362

CAS Number: 75530-68-6
Empirical Formula (Hill Notation): C19H19N3O6
Molecular Weight: 385.37
Linear Formula: C19H19N3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0945-10MG 10 mg
 $50.80
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45-SML0945-50MG 50 mg
 $143.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
InChI key FAIIFDPAEUKBEP-UHFFFAOYSA-N
Quality Level 100 
SMILES string [N+](=O)([O-])c1cc(ccc1)C2C(=C(NC(=C2C(=O)OC)C#N)C)C(=O)OC(C)C
solubility DMSO: 15 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: Nilvadipine is a potent calcium channel blocker that is used for treatment of hypertension. Nilvadipine, as other dihydropyridine calcium antagonists, decreases intracellular calcium concentration causing dilation of the coronary and systemic arteries. Nilvadipine acutely reduced brain Aβ levels in a transgenic mouse model of Alzheimer′s disease (AD).
Biochem/physiol Actions: Nilvadipine is a potent calcium channel blocker; antihypertensive; antianginal.
Biochem/physiol Actions: Nilvadipine, apart from its antihypertensive effect, is known to decrease the accumulation of β-amyloid protein in the brain. Therefore, it is effective in the treatment of Alzheimer’s disease. Nilvadipine also promotes cognitive function in hypertensive patients.
General description: Nilvadipine is a dihydropyridine drug.
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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