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Lacidipine

SIGMA/SML0946 - ≥98% (HPLC)

Synonym: 3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester; CID 5311217; GR-43659X; GX-1048

CAS Number: 103890-78-4
Empirical Formula (Hill Notation): C26H33NO6
Molecular Weight: 455.54
Linear Formula: C26H33NO6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0946-50MG 50 mg
 $268.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InChI key GKQPCPXONLDCMU-CCEZHUSRSA-N
Quality Level 100 
SMILES string N1C(=C(C(C(=C1C)C(=O)OCC)c2c(cccc2)C=CC(=O)OC(C)(C)C)C(=O)OCC)C
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension.
Biochem/physiol Actions: Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352106

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