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4μ8C

SIGMA/SML0949 - ≥98% (HPLC)

Synonym: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

CAS Number: 14003-96-4
Empirical Formula (Hill Notation): C11H8O4
Molecular Weight: 204.18
Linear Formula: C11H8O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0949-5MG 5 mg
 $121.00
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45-SML0949-25MG 25 mg
 $491.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3
InChI key RTHHSXOVIJWFQP-UHFFFAOYSA-N
Quality Level 100 
SMILES string O1c2c(ccc(c2C=O)O)C(=CC1=O)C
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: 4μ8C is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. 4μ8C inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of XBP1 mRNA in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.
Biochem/physiol Actions: 4μ8C is a potent inhibitor of the ER transmembrane protein IRE1.
Biochem/physiol Actions: 4μ8C is a salicylaldehyde derivative and its inhibitory action targets the K907 lysine residue in RNase (ribonuclease) domain and affects IRE1α (endoplasmic reticulum to nucleus signaling 1) RNase activity. In vitro analysis proved that 4μ8C was able to inhibit the release of insulin at high glucose levels.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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