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Salubrinal

SIGMA/SML0951 - ≥98% (HPLC)

Synonym: (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl] 2-propenamide

CAS Number: 405060-95-9
Empirical Formula (Hill Notation): C21H17Cl3N4OS
Molecular Weight: 479.81
Linear Formula: C21H17Cl3N4OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0951-5MG 5 mg
 $129.00
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45-SML0951-25MG 25 mg
 $527.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color , White to brown to grey
form powder
InChI 1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
InChI key LCOIAYJMPKXARU-VAWYXSNFSA-N
Quality Level 100 
SMILES string S=C(NC(NC(=O)C=Cc3ccccc3)C(Cl)(Cl)Cl)Nc1c2ncccc2ccc1
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Application: Salubrinal has been used to study the effect of stress-protective genes and pathways on organism development and lifespan. It has also been used to study the therapeutic potential of salubrinal in methamphetamine induced blood–brain barrier disruption.
Biochem/physiol Actions: Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.
Biochem/physiol Actions: Salubrinal is a selective Inhibitor of eIF2α dephosphorylation; specific inhibitor of ER Stress induced apoptosis.
Biochem/physiol Actions: Salubrinal maintains protein phosphorylation in order to offer protection against from the adverse effects of endoplasmic reticulum stress. Salubrinal prevents collagenase-mediated articular cartilage damage promoting downregulation of matrix metalloproteinase 13.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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