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Dexmedetomidine hydrochloride

SIGMA/SML0956 - ≥98% (HPLC)

Synonym: (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride; 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride; 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

CAS Number: 145108-58-3
Empirical Formula (Hill Notation): C13H16N2 · HCl
Molecular Weight: 236.74
Linear Formula: C13H16N2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0956-10MG 10 mg
 $119.00
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45-SML0956-50MG 50 mg
 $501.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
InChI key VPNGEIHDPSLNMU-MERQFXBCSA-N
optical activity [α]/D +48 to +58°, c = 1 in H2O
Quality Level 100 
SMILES string [Cl-].[N+H2]1C=NC=C1[C@@H](C)c2c(c(ccc2)C)C
solubility H2O: 20 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.
Biochem/physiol Actions: Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.
Biochem/physiol Actions: Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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