Kobe0065

SIGMA/SML0961 - ≥98% (HPLC)

Synonym: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide

CAS Number: 436133-68-5
Empirical Formula (Hill Notation): C₁₅H₁₁ClF₃N₅O₄S
Molecular Weight: 449.79
Linear Formula: C₁₅H₁₁ClF₃N₅O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0961-5MG	5 mg	$88.30 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
InChI key	KSJVAYBCXSURMQ-UHFFFAOYSA-N
Quality Level	100
SMILES string	FC(F)(F)c1cc(c(c(c1)[N+](=O)[O-])NNC(=S)Nc2cc(c(cc2)C)Cl)[N+](=O)[O-]
solubility	DMSO: 15 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. The compound Kobe0065 also inhibts tumor growth in SW480 colon cancer cell xenografts.
Biochem/physiol Actions:	Kobe0065 is an inhibitor of Ras activity.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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