KNK437
SIGMA/SML0964 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 218924-25-5
Empirical Formula (Hill Notation): C13H11NO4
Molecular Weight: 245.23
Linear Formula: C13H11NO4
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C13H11NO4/c15-7-14-4-3 |
| InChI key | LZGGUFLRKIMBDQ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | N1(CCC(=Cc2cc3c(cc2)OCO3) |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | room temp |
| Application: | KNK437 has been used: • as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells • as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells • as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release |
| Biochem/physiol Actions: | KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin. |
| Biochem/physiol Actions: | KNK437 is a heat shock protein inhibitor. |
| Biochem/physiol Actions: | KNK437 is a benzylidene lactam compound. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |