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FLI-06

SIGMA/SML0975 - ≥98% (HPLC)

Synonym: 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester

CAS Number: 313967-18-9
Empirical Formula (Hill Notation): C25H30N2O5
Molecular Weight: 438.52
Linear Formula: C25H30N2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0975-5MG 5 mg
 $111.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
InChI key SWWVFYHSSOWZMF-UHFFFAOYSA-N
Quality Level 100 
SMILES string [N+](=O)([O-])c1ccc(cc1)C2C3=C(NC(=C2C(=O)OC4CCCCC4)C)CC(CC3=O)(C)C
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: FLI-06 is an inhibitor of Notch signaling.
Biochem/physiol Actions: FLI-06 is an inhibitor of Notch signaling. FLI-06 acts upstream of α-secretase and β-secretase cleavage, disrupting intracellular trafficking and processing of the Notch signaling pathway and inhibiting general secretion at a step before exit from the endoplasmic reticulum (ER). This inhibition is accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 does not act on the cytoskeleton, but causes a complete disruption of the Golgi in a manner different from that of Brefeldin A or Golgicide A. FLI-06 is the first compound acting that early in the secretory pathway.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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