JW651
SIGMA/SML0990 - ≥98% (HPLC)
Synonym: 1,1,1,3,3,3-
CAS Number: 1438416-22-8
Empirical Formula (Hill Notation): C21H18Cl2F6N2O2
Molecular Weight: 515.28
MDL Number: MFCD28137685
Linear Formula: C21H18Cl2F6N2O2
Product Type: Chemical
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This image depicts SML0990-5MG.
This image depicts SML0990-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C21H18Cl2F6N2O2/c22-15 |
| InChI key | UPIHQFKOCOKGEO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | ClC1=CC=C(C(C2=CC=C(Cl)C= |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | JW651 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). JW651 inhibited mouse MAGL with an IC50 ~38 nM compared to 10,380 for ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG and >100,000 for FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). JW651 was used as the MAGL inhibitor along with JW912, a fluorescent inihibitor of both MAGL and ABHD6. |
| Biochem/physiol Actions: | JW651 is a potent selective inhibitor of MAGL; active in vivo. |
| Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |