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Ospemifene

SIGMA/SML0996 - ≥98% (HPLC)

Synonym: (deaminohydroxy)toremifene; 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol; FC-1271a

CAS Number: 128607-22-7
Empirical Formula (Hill Notation): C24H23ClO2
Molecular Weight: 378.89
Linear Formula: C24H23ClO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0996-10MG 10 mg
 $86.40
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45-SML0996-50MG 50 mg
 $281.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
InChI key LUMKNAVTFCDUIE-VHXPQNKSSA-N
Quality Level 100 
SMILES string ClCCC(=C(c3ccc(cc3)OCCO)/c2ccccc2)c1ccccc1
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Ospemifene is a selective estrogen receptor modulator (SERM), a metabolite of toremifene, with a unique estrogen agonist/antagonist tissue profile. Ospemifene was recently approved in the US for the treatment of dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is being investigated for the treatment and prevention of osteoporosis and breast cancer. Ospemifene binds ERα and ERβ with approximately equal affinities with IC50 values for estrogen receptor (ER) α and β of 0.8 μM and 1.7 μM, respectively. Ospemifene has estrogen-like effects on the vaginal epithelium and bone, antiproliferative effects in breast, and a neutral endometrial profile.
Biochem/physiol Actions: Ospemifene is a selective estrogen receptor modulator (SERM), a metabolite of toremifene.
Packaging: 10, 50 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H410
Precautionary statements P273 - P501
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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