AdipoRon
SIGMA/SML0998 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 924416-43-3
Empirical Formula (Hill Notation): C27H28N2O3
Molecular Weight: 428.52
Linear Formula: C27H28N2O3
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C27H28N2O3/c30-26(28-2 |
| InChI key | SHHUPGSHGSNPDB-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | N2(CCC(CC2)NC(=O)COc3ccc( |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | room temp |
| Biochem/physiol Actions: | AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice. |
| Biochem/physiol Actions: | AdipoRon is an adiponectin agonist. |
| Biochem/physiol Actions: | Oral administration of adipoRon reduced postischemic oxidative stress showing lower expression of NADPH (Nicotinamide adenine diphosphate) oxidase and superoxide production in mouse model. Hence, adipoRon might be considered as a cardioprotective molecule. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 51111800 |