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ME0328

SIGMA/SML0999 - ≥98% (HPLC)

Synonym: (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide

CAS Number: 1445251-22-8
Empirical Formula (Hill Notation): C19H19N3O2
Molecular Weight: 321.37
Linear Formula: C19H19N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0999-5MG 5 mg
 $88.40
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
InChI key QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Quality Level 100 
SMILES string [nH]1c2c([c](nc1CCC(=O)N[C@@H](C)c3ccccc3)=O)cccc2
solubility DMSO: 10 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair.
Biochem/physiol Actions: ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair. ME0328 is the most potent isomer of the four ARTD3 ADP-ribosyltransferase inhibitors. ME0328 selectively inhibits ARTD3 (IC50 of 890 nM) with weaker activity against ARTD1 and ARTD2 (IC50 6.3 and 10.8 μM, respectively), and no significant activity (IC50 >30 μM) against any other ARTD enzyme. ME0328 appears to be the first selective inhibitor of ARTD3/PARP3.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22-43
Safety Statements 36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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