ME0328

SIGMA/SML0999 - ≥98% (HPLC)

Synonym: (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide

CAS Number: 1445251-22-8
Empirical Formula (Hill Notation): C₁₉H₁₉N₃O₂
Molecular Weight: 321.37
Linear Formula: C₁₉H₁₉N₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0999-5MG	5 mg	$119.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
InChI key	QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Quality Level	100
solubility	DMSO: 10 mg/mL, clear
storage temp.	room temp

Biochem/physiol Actions:	ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair. ME0328 is the most potent isomer of the four ARTD3 ADP-ribosyltransferase inhibitors. ME0328 selectively inhibits ARTD3 (IC₅₀ of 890 nM) with weaker activity against ARTD1 and ARTD2 (IC₅₀ 6.3 and 10.8 μM, respectively), and no significant activity (IC₅₀ >30 μM) against any other ARTD enzyme. ME0328 appears to be the first selective inhibitor of ARTD3/PARP3.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22-43
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.