L-742001 hydrochloride

SIGMA/SML1010 - ≥98% (HPLC)

Synonym: (Z)-4-[1-Benzyl-4-[(4-chlorophenyl)methyl]piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid hydrochloride; 4-[4-[(4-Chlorophenyl)methyl]-1-(phenylmethyl)-4-piperidinyl]-2-hydroxy-4-oxo-2-butenoic acid hydrochloride; L-742,001 hydrochloride; L742001 hydrochloride

CAS Number: 174605-64-2
Empirical Formula (Hill Notation): C₂₃H₂₄ClNO₄ · HCl
Molecular Weight: 450.35
MDL Number: MFCD22587878
Linear Formula: C₂₃H₂₄ClNO₄ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1010-5MG	5 mg	$164.00 1/EA	Add To Favorites
45-SML1010-25MG	25 mg	$655.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18;/h1-9,14,26H,10-13,15-16H2,(H,28,29);1H/b20-14-;
InChI key	LMLNSXCRZNNZBT-VSOKSMTPSA-N
Quality Level	100
SMILES string	O/C(C(O)=O)=CC(C(CC1)(CC2=CC=C(Cl)C=C2)CCN1CC3=CC=CC=C3)=O.Cl
solubility	DMSO: 20 mg/mL, clear
storage condition	desiccated
storage temp.	2-8°C

Biochem/physiol Actions:	L-742,001 is an inhibitor of the influenza virus RNA polymerase PA subunit.
Biochem/physiol Actions:	L-742,001 is an inhibitor of the influenza virus RNA polymerase PA subunit, implicated in several roles, including endonuclease and protease activities as well as viral RNA/complementary RNA promoter binding. L-742,001 inhibits the influenza endonuclease-dependent polymerase activity with an IC₅₀ of 430 nM.
Biochem/physiol Actions:	L-742001 is useful in the treatment of influenza viral infection.

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 - H410
Precautionary statements	P273 - P301 + P312 + P330
Hazard Codes	Xn,N
Risk Statements	22-50/53
Safety Statements	46-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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