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PRT4165

SIGMA/SML1013 - ≥98% (HPLC)

Synonym: 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethylene)-1,3-indandione; NSC 600157

CAS Number: 31083-55-3
Empirical Formula (Hill Notation): C15H9NO2
Molecular Weight: 235.24
MDL Number: MFCD00435709
Linear Formula: C15H9NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1013-5MG 5 mg
 $109.00
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45-SML1013-25MG 25 mg
 $429.00
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assay ≥98% (HPLC)
color white to gray
form powder
InChI 1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
InChI key OMHZFEWYVFWVLI-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1C(C(C2=C1C=CC=C2)=O)=CC3=CN=CC=C3
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.
Biochem/physiol Actions: PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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