CYM-5520
SIGMA/SML1014 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 1449747-00-5
Empirical Formula (Hill Notation): C21H19N3O2
Molecular Weight: 345.39
Linear Formula: C21H19N3O2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | CYM-5520 has been used as a sphingosine 1-phosphate receptor 2 (S1pr2) agonist in pancreatic adenocarcinoma cell line (CFPAC-1). |
| Biochem/physiol Actions: | CYM-5520 is a specific, noncompetitive allosteric agonist of sphingosine 1-phosphate receptor 2 (S1PR2; EC50 = 1.0 μM). The compound CYM-5520 does not show any agonsit activity towards S1PR1, S1PR3, S1PR4 or S1PR5. |
| Biochem/physiol Actions: | CYM-5520 is a specific, noncompetitive allosteric agonist of sphingosine 1-phosphate receptor 2. |
| Biochem/physiol Actions: | CYM-5520 mediates phosphorylation of transcription factor p65. It upregulates trabecular number, thickness as well as tibial bone volume density in osteoblasts. |
| Hazard Codes | T |
| Risk Statements | 25-41 |
| Safety Statements | 26-39-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352211 |