Cyclosporin A, Ready Made Solution
SIGMA/SML1018 - 1 mg/mL in DMSO
Synonym: CsA; Cyclosporine
CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C62H111N11O12
Molecular Weight: 1202.61
EC Number: 200-664-3
Linear Formula: C62H111N11O12
Product Type: Chemical
| concentration | 1 mg/mL in DMSO |
| form | DMSO solution |
| InChI | 1S/C62H111N11O12/c1-25-27 |
| InChI key | PMATZTZNYRCHOR-IMVLJIQESA |
| Quality Level | 200  |
| shipped in | dry ice |
| storage condition | protect from light |
| storage temp. | −20°C |
| Application: | Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model. |
| Biochem/physiol Actions: | Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+- and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes. At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin. CsA can inhibit IL2 production resulting from T cell activation via Calcineurin inhibition. An extensive list of references has been reported, including a comprehensive review of analytical properties. |
| Biochem/physiol Actions: | Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects. |
| Other Notes: | Light sensitive |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 188.6 °F - closed cup |
| Flash Point(C) | 87 °C - closed cup |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |