Cyclosporin A, Ready Made Solution

SIGMA/SML1018 - 1 mg/mL in DMSO

Synonym: CsA; Cyclosporine

CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C₆₂H₁₁₁N₁₁O₁₂
Molecular Weight: 1202.61
EC Number: 200-664-3
Linear Formula: C₆₂H₁₁₁N₁₁O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1018-1ML	1 mL	$164.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

concentration	1 mg/mL in DMSO
form	DMSO solution
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
InChI key	PMATZTZNYRCHOR-IMVLJIQESA-N
Quality Level	200
shipped in	dry ice
SMILES string	N1(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C1=O)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)CC)C(O)C(CC=CC)C)C
storage condition	protect from light
storage temp.	−20°C

Application:	Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.
Biochem/physiol Actions:	Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.
Biochem/physiol Actions:	Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca²⁺- and calmodulin-dependent protein phosphatase,inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin.CsA can inhibit IL₂production resulting from T cell activation via Calcineurin inhibition. An extensive list of references has been reported, including a comprehensive review of analytical properties.
Biochem/physiol Actions:	Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.
Other Notes:	Light sensitive

RIDADR	NA 1993 / PGIII
WGK Germany	WGK 1
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Storage Temp.	−20°C
UNSPSC	12352200

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