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BC-1258

SIGMA/SML1021

Synonym: N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine

CAS Number: 1507370-40-2
Empirical Formula (Hill Notation): C22H22N4S2
Molecular Weight: 406.57
MDL Number: MFCD28137686
Linear Formula: C22H22N4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1021-5MG 5 mg
 $0.00
1/EA
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45-SML1021-25MG 25 mg
 $0.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2
InChI key FRTSLZJCGAFSET-UHFFFAOYSA-N
Quality Level 100 
SMILES string C1(C2=NC=CS2)=CC=C(CNCCNCC3=CC=C(C4=NC=CS4)C=C3)C=C1
solubility DMSO: 10 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: BC-1258 is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. BC-1258 induces mitotic arrest and apoptosis of tumorigenic cells. Also BC-1258 inhibits tumor formation in athymic nude mice.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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