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AS1949490

SIGMA/SML1022 - ≥98% (HPLC)

Synonym: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide; AS 1949490

CAS Number: 1203680-76-5
Empirical Formula (Hill Notation): C20H18ClNO2S
Molecular Weight: 371.88
Linear Formula: C20H18ClNO2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1022-5MG 5 mg
 $121.00
1/EA		 Add To Favorites
45-SML1022-25MG 25 mg
 $332.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H18ClNO2S/c1-14(16-5-3-2-4-6-16)22-20(23)19-18(11-12-25-19)24-13-15-7-9-17(21)10-8-15/h2-12,14H,13H2,1H3,(H,22,23)/t14-/m0/s1
InChI key RFZPGNRLOKVZJY-AWEZNQCLSA-N
Quality Level 100 
SMILES string [s]1c(c(cc1)OCc3ccc(cc3)Cl)C(=O)N[C@@H](C)c2ccccc2
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: AS1949490 is a potent, selective SHIP2 phosphatase inhibitor.
Biochem/physiol Actions: AS1949490 is a potent, selective SHIP2 phosphatase inhibitor. AS1949490 activates insulin signaling pathways in liver and lowers glucose levels in diabetic mice.
Biochem/physiol Actions: AS1949490 is also known as (3-[(4-chlorobenzyl)oxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide). It enhances the phosphorylation of Akt, glucose consumption and glucose uptake in L6 myotubes. AS1949490 has the ability to block gluconeogenesis in FAO (cell line) hepatocytes.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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