Imatinib mesylate

SIGMA/SML1027 - ≥98% (HPLC)

Synonym: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate; 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide mesylate; CGP 57148; Genfatinib; Glivec; Imatinib methanesulfonate; STI-571

CAS Number: 220127-57-1
Empirical Formula (Hill Notation): C₂₉H₃₁N₇O · CH₄O₃S
Molecular Weight: 589.71
Linear Formula: C₂₉H₃₁N₇O · CH₄O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1027-10MG	10 mg	$48.00 1/EA	Add To Favorites
45-SML1027-100MG	100 mg	$164.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
InChI key	YLMAHDNUQAMNNX-UHFFFAOYSA-N
Quality Level	100
SMILES string	[S](=O)(=O)([O-])C.[N+H]1(CCN(CC1)Cc2ccc(cc2)C(=O)Nc3cc(c(cc3)C)Nc4nc(ccn4)c5cnccc5)C
solubility	H₂O: 10 mg/mL, clear
storage condition	desiccated
storage temp.	2-8°C

Application:	Imatinib mesylate (IM) has been used: • in sulforhodamine B cell viability assay to study its effect on CD34⁺ or CD38^- and CD34⁺ or CD38⁺ cells • as an abelson1 (ABL1) kinase inhibitor • in circular dichroism analysis to study the effect of IM binding on the secondary structure of the human transferrins
Biochem/physiol Actions:	Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity.
Biochem/physiol Actions:	Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib is a potent inhibitor of the Bcr-Abl kinase encoded by the bcr-abl oncogene as well as receptor tyrosine kinases encoded by c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib mesylate inhibition of Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML decreases proliferation and enhances apoptosis in leukemias CML and ALL. Inhibition of c-kit tyrosine activity inhibits mast-cell and cellular proliferation in those diseases overexpressing c-kit such as gastrointestinal stromal tumor (GIST).
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes:	Imatinib has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Imatinib probe summary on the Chemical Probes Portal website.
Packaging:	10, 100 mg in glass bottle

Symbol	GHS08
Signal word	Warning
Hazard statements	H361d
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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