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Bioymifi

SIGMA/SML1031 - ≥98% (HPLC)

Synonym: (Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione

CAS Number: 1420071-30-2
Empirical Formula (Hill Notation): C22H12BrN3O4S
Molecular Weight: 494.32
Linear Formula: C22H12BrN3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1031-5MG 5 mg
 $140.00
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45-SML1031-25MG 25 mg
 $430.00
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assay ≥98% (HPLC)
color , orange to dark orange red
form powder
InChI 1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22?
InChI key ULBOWKXOFOTCMU-NLDKGBHCSA-N
Quality Level 100 
solubility DMSO: 2 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Bioymifi induces apoptosis via the Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) death receptor DR5 independent of TRAIL. Bioymifi binds selectively to the extracellular domain of DR5 with little binding affinity to DR4, promoting DR5 aggregation and activation. Bioymifi caused apoptosis and cell death in a variety of human cancer cell lines including T98G human glioblastoma cells, lung cancer cell lines H460 and H1155, the cervical cancer cell line HeLa, the osteosarcoma cell line U2OS, the pancreatic carcinoma cell line Miapaca and the colon cancer cell line HT29.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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