Synonym: (9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-thieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide
CAS Number: 227609-66-7
Empirical Formula (Hill Notation): C17H15BrFNO3S
Molecular Weight: 412.27
Linear Formula: C17H15BrFNO3S
Product Type: Chemical
assay |
≥98% |
color |
white to beige |
form |
powder |
optical activity |
[α]/D -44 to -54°, c = 0.1 in acetonitrile |
Quality Level |
100 |
solubility |
DMSO: 5 mg/mL, clear (warmed) |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
A-278637 is a selective opener of ATP-sensitive K (KATP) channels (EC50 = 102 nM) that blocks contraction of bladder smooth muscle in both in vivo and in vitro assays. A-278637 is 15-fold more selective than nifedipine for bladder compared other smooth muscle KATP channels, and displays reduced effects on mean arterial pressure compared to other channel openers. |
Packaging: |
5, 25 mg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |