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A-278637

SIGMA/SML1033 - ≥98%

Synonym: (9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-thieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide

CAS Number: 227609-66-7
Empirical Formula (Hill Notation): C17H15BrFNO3S
Molecular Weight: 412.27
Linear Formula: C17H15BrFNO3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1033-25MG 25 mg
 $251.00
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assay ≥98%
color white to beige
form powder
optical activity [α]/D -44 to -54°, c = 0.1 in acetonitrile
Quality Level 100 
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: A-278637 is a selective opener of ATP-sensitive K (KATP) channels (EC50 = 102 nM) that blocks contraction of bladder smooth muscle in both in vivo and in vitro assays. A-278637 is 15-fold more selective than nifedipine for bladder compared other smooth muscle KATP channels, and displays reduced effects on mean arterial pressure compared to other channel openers.
Biochem/physiol Actions: A-278637 is a selective opener of ATP-sensitive K (KATP) channels.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
Storage Temp. 2-8°C
UNSPSC 12352202

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