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ICA-121431

SIGMA/SML1035 - ≥98% (HPLC)

Synonym: α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide

CAS Number: 313254-51-2
Empirical Formula (Hill Notation): C23H19N3O3S2
Molecular Weight: 449.55
Linear Formula: C23H19N3O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1035-5MG 5 mg
 $120.00
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45-SML1035-25MG 25 mg
 $476.00
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assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
solubility DMSO: 20 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels.
Biochem/physiol Actions: ICA-121431 [2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl) acetamide, a small molecule inhibitor, targets the extracellular amino acids in S2 and S3 in VSDIV (domain IV voltage sensor), which is essential for Hm1a efficacy. In humans, ICA-121431 blocks TTX-sensitive Nav1.3 sodium channels upregulated in HEK-293 cells.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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