ENMD-1068 hydrochloride
SIGMA/SML1039 - ≥97% (HPLC)
Synonym: 6-
CAS Number: 789488-77-3 (free base)
Empirical Formula (Hill Notation): C15H29N3O2 · HCl
Molecular Weight: 319.87
Linear Formula: C15H29N3O2 · HCl
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C15H29N3O2/c1-13(2)12- |
| InChI key | VRZYMMVEALDDBH-UHFFFAOYSA |
| Quality Level | 100  |
| solubility | H2O: 25 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2). |
| Biochem/physiol Actions: | ENMD-1068 hydrochloride exhibits anti-angiogenic and anti-inflammatory activities. |
| Biochem/physiol Actions: | ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 46 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |