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KC7F2

SIGMA/SML1043 - ≥98% (HPLC)

Synonym: N,N′-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide

CAS Number: 927822-86-4
Empirical Formula (Hill Notation): C16H16Cl4N2O4S4
Molecular Weight: 570.38
MDL Number: MFCD22683809
Linear Formula: C16H16Cl4N2O4S4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1043-1MG 1 mg
 $46.50
1/EA		 Add To Favorites
45-SML1043-5MG 5 mg
 $76.70
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
InChI key REQLACDIZMLXIC-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string ClC1=CC=C(Cl)C=C1S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: KC7F2 is a cell permeable potent HIF-1 pathway inhibitor. KC7F2 inhibits the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), enolase 1, and endothelin 1. KC7F2 suppresses the protein accumulation of HIF-1? in cancer cell lines by inhibition of its protein synthesis at the translation level. KC7F2 is preferentially cytotoxicity to cancer cells, an effect that is increased in hypoxia.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: air sensitive
Packaging: 1, 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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