Thiazovivin

SIGMA/SML1045 - ≥98% (HPLC)

Synonym: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

CAS Number: 1226056-71-8
Empirical Formula (Hill Notation): C₁₅H₁₃N₅OS
Molecular Weight: 311.36
Linear Formula: C₁₅H₁₃N₅OS
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1045-5MG	5 mg	$149.00 1/EA		Add To Favorites
45-SML1045-25MG	25 mg	$476.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	, white to beige to brown
form	powder
InChI	1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChI key	DOBKQCZBPPCLEG-UHFFFAOYSA-N
Quality Level	100
solubility	DMSO: 20 mg/mL, clear
storage temp.	−20°C

Application:	Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.
Biochem/physiol Actions:	Thiazovivin is a Rho Kinase (ROCK) inhibitor that promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method when used in combination with ALK5 inhibitor SB-431542 (S4317) and MEK inhibitor PD-0325901 (PZ0162). Thiazovivin stabilizes E-cadherin on the cell surface, necessary for human embryonic stem cell survival in culture. When human embryonic stem cells are cut out from the colony, this key protein is disrupted and then internalized within the cell. Without e-cadherin on the cell surface, cell signaling between the cells and their environment is disrupted and the cells quickly die.
Biochem/physiol Actions:	Thiazovivin is an inhibitor of Rho associated coiled-coil containing protein kinase (ROCK). In vitro studies prove that thiazovivin is efficient in stimulating better morphology, expression of ionic transporter and protein involved in cell adhesion.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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