CHIR99021
SIGMA/SML1046 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 252917-06-9
Empirical Formula (Hill Notation): C22H18Cl2N8
Molecular Weight: 465.34
MDL Number: MFCD11846251
Linear Formula: C22H18Cl2N8
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML1046-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML1046-5MG
| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| Quality Level | 100  |
| SMILES string | ClC(C=C1Cl)=CC=C1C2=NC(NC |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Application: | CHIR99021 has been used: • in cocktail with small molecules to convert human lung fibroblast cells into neurons • as a culture medium supplement in potassium supplemented simplex optimization medium (KSOM) for the culture of blastocysts • for chronic inhibition of GSK-3 to investigate its role in corticogenesis |
| Biochem/physiol Actions: | CHIR99021 is a very potent inhibitor of Glycogen synthase kinase 3 (GSK3, IC50 values for GSK3α and GSK3β = 10 and 6.7 nM, respectively). There is no cross-reactivity against CDKs. CHIR99201 potentiates self-renewal of human and mouse embryonic stem cells, and enhances reprogramming of somatic cells into stem cells. |
| General description: | CHIR99021 is an aminopyrimidine derivative. CHIR99021 promotes self-renewal potential of embryonic stem cells (ESCs) of mice by inhibiting glycogen synthase kinase-3 (GSK-3) activity and potentiates the upregulation of β-catenin and c-Myc functions. CHIR99021 promotes self-renewal of ESCs by modulating transforming growth factor β (TGF-β), Notch and mitogen-activated protein kinases (MAPK) signaling pathways. CHIR99021 is an agonist of wingless/integrated (wnt) signalling, upregulates cyclinA expression and promotes cell proliferation in non-small-cell lung cancer (NSCLC) cell lines. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 - H315 - H319 - H335 |
| Precautionary statements | P261 - P264 - P301 + P310 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |