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LMK235

SIGMA/SML1053 - ≥98% (HPLC)

Synonym: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide

CAS Number: 1418033-25-6
Empirical Formula (Hill Notation): C15H22N2O4
Molecular Weight: 294.35
Linear Formula: C15H22N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1053-5MG 5 mg
 $89.70
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45-SML1053-25MG 25 mg
 $365.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19)
InChI key VRYZCEONIWEUAV-UHFFFAOYSA-N
Quality Level 100 
SMILES string N(OCCCCCC(=O)NO)C(=O)c1cc(cc(c1)C)C
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: LMK-235 induces the differentiation of odontoblasts in dental pulp cells. It plays an important role in the regeneration of dental tissue.
Biochem/physiol Actions: LMK235 is a histone deacetylase (HDAC) inhibitor with greater potency against HDAC4 and HDAC5 (IC50 = 11.9 and 4.2 nM, respectively) than other HDAC family members (IC50 values = HDAC1 320 nM, HDAC2 881 nM, HDAC6 55.7 nM, and HDAC8 1278 nM). LMK235 potentiates the cytotoxic effects of cisplatin, and sensitizes platinum-drug resistant tumor cell lines to cisplatin toxicity.
Biochem/physiol Actions: LMK235 is a histone deacetylase (HDAC) inhibitor; HDAC4- and HDAC5-preferring.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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