CX4338
SIGMA/SML1056 - ≥98% (HPLC)
Synonym: 4,4-
CAS Number: 41609-06-7
Empirical Formula (Hill Notation): C22H24N2OS
Molecular Weight: 364.50
Linear Formula: C22H24N2OS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | CX4338 is a CXCR2 receptor antagonist. In cell based assays, CX4338 blocks CXCL8-induced receptor internalization and β-arrestin recruitment, but enhances G-protein-mediated signaling events such as calcium mobilization and ERK phosporylation. The comopund inhibits CXCL8-induced neutrophil chemotaxis, and LPS-induced PMN migration in a mouse airway inflammaiton model. |
Packaging: | 5, 25 mg in glass bottle |
Hazard Codes | N |
Risk Statements | 50/53 |
Safety Statements | 60-61 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 51111800 |