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PBIT

SIGMA/SML1058 - ≥98% (HPLC)

Synonym: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one; 2-p-Tolyl-1,2-benzisothiazolin-3-one

CAS Number: 2514-30-9
Empirical Formula (Hill Notation): C14H11NOS
Molecular Weight: 241.31
Linear Formula: C14H11NOS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1058-5MG 5 mg
 $129.00
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45-SML1058-25MG 25 mg
 $525.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
InChI key KRXMYBAZKJBJAB-UHFFFAOYSA-N
Quality Level 100 
SMILES string [s]1[n]([c](c3c1cccc3)=O)c2ccc(cc2)C
solubility DMSO: 10 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: S,S′-1,4-phenylenebis(1,2-ethanediyl)bis-isothiourea (PBIT) is an iNOS (inducible nitric oxide synthase) inhibito. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1.
Biochem/physiol Actions: PBIT is a potent inhibitor of JARID1B (KDM5B) histone lysine demethylase that inhibits removal of H3K4me3 in UACC-812 cells. PBIT inhibits proliferation of cells overexpressing JARID1B. PBIT is selective for JARID1 enzymes and does not inhibit demethylases UTX or JMJD3.
Biochem/physiol Actions: PBIT is a potent inhibitor of JARID1B (KDM5B).
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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