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PF-04856264

SIGMA/SML1061 - ≥98% (HPLC)

Synonym: 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide

CAS Number: 1235397-05-3
Empirical Formula (Hill Notation): C20H15N5O3S2
Molecular Weight: 437.49
MDL Number: MFCD28124397
Linear Formula: C20H15N5O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1061-5MG 5 mg
 $137.00
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45-SML1061-25MG 25 mg
 $546.00
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assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)
InChI key MKSKJVIBSRUWSZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=S(C(C=C1)=CC(C#N)=C1OC2=CC=CC=C2C3=CC=NN3C)(NC4=NC=CS4)=O
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC50 = 131 nM) but has low potency against the rat Nav1.7 channel (IC50 = 4.2 mM).
Biochem/physiol Actions: PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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