IMM-01
SIGMA/SML1064 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 218795-74-5
Empirical Formula (Hill Notation): C12H17N3O2S
Molecular Weight: 267.35
Linear Formula: C12H17N3O2S
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| InChI | 1S/C12H17N3O2S/c1-12(2,3) |
| InChI key | LTFUAYRGVLQXKC-NTUHNPAUSA |
| Quality Level | 100  |
| SMILES string | S=C(NN=Cc1c(cc(cc1)O)O) |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs). |
| Biochem/physiol Actions: | IMM-01 binds and activates formin thereby leading to autoinhinition. |
| Biochem/physiol Actions: | IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer. |
| Biochem/physiol Actions: | IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |