Synonym: 2-[(2,4-Dihydroxyphenyl)methylene]-N-(1,1-dimethylethyl)-hydrazinecarbothioamide; Intramimic-01; N1-(tert-Butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide
CAS Number: 218795-74-5
Empirical Formula (Hill Notation): C12H17N3O2S
Molecular Weight: 267.35
Linear Formula: C12H17N3O2S
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to light brown |
form |
powder |
Quality Level |
100 |
solubility |
DMSO: 10 mg/mL, clear |
storage temp. |
2-8°C |
Application: |
IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs). |
Biochem/physiol Actions: |
IMM-01 binds and activates formin thereby leading to autoinhinition. |
Biochem/physiol Actions: |
IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer. |
Packaging: |
5, 25 mg in glass bottle |
Hazard Codes |
Xn |
Risk Statements |
22 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |