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ML240

SIGMA/SML1071 - ≥98% (HPLC)

Synonym: 2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine; CID-49830258

CAS Number: 1346527-98-7
Empirical Formula (Hill Notation): C23H20N6O
Molecular Weight: 396.44
MDL Number: MFCD28137687
Linear Formula: C23H20N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1071-5MG 5 mg
 $139.00
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45-SML1071-25MG 25 mg
 $550.00
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assay ≥98% (HPLC)
color , white to yellow to light brown
form powder
InChI 1S/C23H20N6O/c1-30-19-13-7-10-16-20(19)27-23(28-21(16)25-14-15-8-3-2-4-9-15)29-18-12-6-5-11-17(18)26-22(29)24/h2-13H,14H2,1H3,(H2,24,26)(H,25,27,28)
InChI key NHAMBLRUUJAFOY-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC1=NC2=C(C=CC=C2)N1C3=NC4=C(OC)C=CC=C4C(NCC5=CC=CC=C5)=N3
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.
Biochem/physiol Actions: ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP).
Biochem/physiol Actions: ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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