GSK-LSD1
SIGMA/SML1072 - ≥98% (HPLC)
Synonym: GSK-LSD1 (trans-racemic) dihydrochloride; rel- N-
CAS Number: 1431368-48-7 (free base)
Empirical Formula (Hill Notation): C14H20N2 · 2HCl
Molecular Weight: 289.24
Linear Formula: C14H20N2 · 2HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C14H20N2/c1-2-4-11(5-3 |
InChI key | BASFYRLYJAZPPL-UONOGXRCSA |
Quality Level | 100 |
SMILES string | C1(N[C@@H]2C[C@H]2C3=CC=C |
solubility | H2O: 20 mg/mL, clear |
storage temp. | 2-8°C |
Application: | GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1. |
Biochem/physiol Actions: | GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
Features and Benefits: | GSK-LSD1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC . |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |