Synonym: 2,2,3,3-Tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide; N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
CAS Number: 329059-55-4
Empirical Formula (Hill Notation): C28H36N2O4S
Molecular Weight: 496.66
MDL Number: MFCD02168947
Linear Formula: C28H36N2O4S
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C28H36N2O4S/c1-25(2)21(26(25,3)4)23(31)29-17-9-13-19(14-10-17)35(33,34)20-15-11-18(12-16-20)30-24(32)22-27(5,6)28(22,7)8/h9-16,21-22H,1-8H3,(H,29,31)(H,30,32) |
| InChI key |
UHXFWAHRAMUDLJ-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC(C1C(NC(C=C2)=CC=C2S(C3=CC=C(NC(C4C(C)(C(C)4C)C)=O)C=C3)(=O)=O)=O)(C(C)1C)C |
| solubility |
DMSO: 10 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
BRD7116 is a selective inhibitor of leukemia stem cells. BRD7116 had an EC50 of 200 nM for the leukemia stem cell (LSC)-enriched fraction of cells isolated from the bone marrow of leukemic animals in co-culture compared to ~50% inhibition at 20 μM against normal hematopoietic stem and progenitor cells (HSPCs) and AML cell lines. BRD7116 selectively targeted LSCe cells by cell-autonomous and cell-non-autonomous mechanisms. The exact mechanism is not known, but involved in impairing of the stroma’s ability to support leukemia cells, and inducing transcriptional changes consistent with myeloid differentiation. |
| Features and Benefits: |
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| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
