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BX-912

SIGMA/SML1086 - ≥95% (HPLC)

Synonym: N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

CAS Number: 702674-56-4
Empirical Formula (Hill Notation): C20H23BrN8O
Molecular Weight: 471.35
Linear Formula: C20H23BrN8O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1086-5MG 5 mg
 $117.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI key DMMILYKXNCVKOJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1c(nc(nc1)Nc3cc(ccc3)NC(=O)N4CCCC4)NCCc2nc[nH]c2
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: BX-912 is a potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). The IC50 values for direct inhibition of kinase activity or inhibition in a cell based assay are 26 nM and 12 nM, respectively. BX-912 inhibits the growth of PC-3 tumor cells grown on soft agar more potently than cells grown on plastic (IC50 = 320 nM vs. 5.5 mM, respectively).
Biochem/physiol Actions: PDK1 inhibitor
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P261 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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